PY25405 Dosage Forms Technology – I – Semester IV – Pharma – R-2025

Subject Code & Name: PY25405 – Dosage Forms Technology – I

Regulation: R-2025

Semester: IV (Fourth Semester)

Branch: B.Tech. Pharmaceutical Technology (Pharma)

Credits / L-T-P: 3 Credits | L-T-P: 3-0-0

Course Objectives

• To acquire the skills in design, formulation and characterize pharmaceutical dosage forms.

Full Unit-wise Syllabus

Unit I – Dosage Form Design Formulation Considerations

Need for Dosage Forms - Preformulation Studies – Bulk Characterization – Solubility and pH – Molecular dissociation - pKa – log P – Dissolution rate – Salt selection – Polymorphism – Stability Analysis – Pharmaceutical Excipients in solid dosage forms.

Activities: Group discussions, quizzes, MCQs, assignments, case-based analysis, and visual learning activities on preformulation studies, physicochemical properties, polymorphism, stability, excipients, and dosage form selection.

Unit II – Powders and Granules

Advantages and disadvantages of powdered and granulated products, Mixing and dividing of powders, Problems in manufacturing powders, Reasons for granulation, Granulation mechanisms, Granulation methods, pharmaceutical granulation equipment’s.

Activities: Group discussions, quizzes, MCQs, assignments, process design exercises, and visual learning activities on powder handling, granulation methods, granulation mechanisms, and pharmaceutical equipment selection.

Unit III – Tablets and Capsules

Types of tablets, Formulation, Manufacturing of tablets, Tableting problems, Evaluation of Tablets, Tabletting equipments - Machine Tooling. Capsules – Classification, Gelatin and Non-gelatin Capsules – Hard gelatin capsules, Composition and size, Materials and methods for production of hard gelatin capsule, Formulation and filling of capsules, Soft gelatin capsules, Rationale, Manufacturing and formulation of soft gelatin capsules, Evaluation of capsules

Activities: Group discussions, quizzes, MCQs, assignments, formulation-based exercises, and visual learning activities on tablet and capsule formulation, manufacturing, evaluation, defects, and pharmaceutical equipment.

Unit IV – Coating and Encapsulation

Tablet coating, Film coating, Sugar Coating, Enteric coating, Quality Control Tests, Applications, Equipments in Large Scale Manufacture. Microencapsulation in pharmaceutical technology, Microencapsulation by coacervation, Phase separation, Multi-orifice centrifugation, Spray congealing, Polymerization, Air suspension technique, Pan coating and other techniques, Quality control of microcapsules.

Activities: Group discussions, quizzes, MCQs, assignments, comparative analysis, and visual learning activities on coating techniques, drug release behavior, microencapsulation methods, quality control, and large-scale manufacturing applications.

Course Outcomes (COs)

• CO1: Understand the principles of preformulation studies and their significance in pharmaceutical dosage form development.
• CO2: Explain the properties and processing characteristics of pharmaceutical powders and granules.
• CO3: Apply formulation and characterization techniques for the development of tablets and capsules.
• CO4: Analyze coating processes and evaluate their impact on dosage form performance and stability.
• CO5: Evaluate microencapsulation techniques for improving drug delivery, stability, and therapeutic effectiveness.
• CO6: Design and characterize pharmaceutical dosage forms by integrating preformulation, formulation, and evaluation principles.

Assessment Pattern (Quick Note)

• Weightage: Continuous Assessment 40% | End Semester Examinations 60%
• Internal methodology: Assignments (20%), Solution to application-oriented problems using software (20%), Solving of GATE questions (20%), Internal Examinations (40%)

Source: Official Anna University – B.Tech. Pharmaceutical Technology R-2025 Syllabus
Last Updated: October 2026