BM25C10 Biocontrol System – Semester IV – BME / MedElec – R-2025

Subject Code & Name: BM25C10 – Biocontrol System

Regulation: R-2025

Semester: IV (Fourth Semester)

Branch: B.E. Biomedical Engineering (BME) / B.E. Medical Electronics (MedElec)

Credits / L-T-P: 3 Credits | L-T-P: 3-0-0

Course Objectives

• To present a clear exposition of the classical methods of control engineering and to describe physical system modeling, and basic principles of frequency and time domain design techniques.
• To teach the practical control system design with realistic system specifications and to provide knowledge of physiological control system concept and design.

Full Unit-wise Syllabus

Unit I – Introduction to Control Systems

block diagram of control system – Open loop and closed loop – Applications and scope. Introduction to Physiological control systems- Illustration, Linear models of physiological systems, Difference between engineering and physiological control systems.

Unit II – Mathematical Modeling

electrical and mechanical systems – Equivalence between the elements of different types of systems, Mathematical Modeling of systems, Block diagram and signal flow graph representation of systems – reduction of block diagram and signal flow graph.

Unit III – Time Domain Response

Step and impulse responses of first order systems, step responses of second order systems – time domain specifications of first and second order systems – steady state error constants. Controllers – P, PI, PID controllers.

Unit IV – Stability Analysis

Concept and definition, Poles, Zeros, Order and Type of systems, Routh- Hurwitz criteria of stability, Root locus technique – construction of root locus and study of stability.

Unit V – Frequency Response Analysis

specifications – Polar plots – Bode plots – Nyquist plot – Nyquist stability criterion, closed loop stability – Constant M and N circles – Nichol‘s chart. Stability analysis in frequency domain.

Unit VI – Biological Control System Analysis

Model development of Cardiovascular system- Heart model-circulatory model, Pulmonary mechanics- Interaction of Pulmonary and Cardiovascular models, Regulation of cardiac output, steady state analysis of muscle stretch reflex action, transient response analysis of neuromuscular reflex model action, frequency response of circulatory control model, Stability analysis of Pupillary light reflex.

Activities: Design of lung model using Simulation software (MATLAB). Modeling of Cardiac output regulation using Simulation software (CVSIM/MATLAB/etc..)

Course Outcomes (COs)

• CO1: Explain the fundamental concepts of control systems, including open-loop and closed-loop systems, block diagrams, and physiological control system models.
• CO2: Develop mathematical models of electrical, mechanical, and physiological systems and represent them using block diagrams and signal flow graphs.
• CO3: Analyze time-domain and frequency-domain responses of control systems, including stability analysis.
• CO4: Apply simulation tools (MATLAB, CVSIM) to design and analyze physiological control models such as lung dynamics and cardiac output regulation.

Assessment Pattern (Quick Note)

• Weightage: Continuous Assessment 40% | End Semester Examinations 60%
• Internal methodology: Modelling using software (30%), Solving of GATE questions (30%), Internal Examinations (40%)

Source: Official Anna University – B.E. Biomedical Engineering R-2025 Syllabus
Last Updated: October 2026