Subject Code & Name: BT25201 – Bioorganic Chemistry
Regulation: R-2025
Semester: II (Second Semester)
Branch: B.Tech. Biotechnology (Biotech)
Credits / L-T-P: 3 Credits | L-T-P: 3-0-0
Course Objectives
- To introduce the chemical principles linking organic chemistry and biology, focusing on bio molecular interactions, stereochemistry, mechanism of organic reactions, carbohydrates and protein chemistry.
Full Unit-wise Syllabus
Unit I – Introduction to Bioorganic Chemistry
Basic considerations; Historical Connection between Organic and Biological Chemistry; Weak Interactions in Organic and Biological World; Proximity Effects in Organic Chemistry; Molecular Adaptation; Molecular Recognition and the Supramolecular Level.
Activities: Seminar on Historical Connection between Organic and Biological Chemistry.
Unit II – Bonding and Stereochemistry
Atoms, Electrons and orbitals; Covalent Bonds; Octet rule; Polar covalent Bonds; Electro negativity; formal charge; Arrhenius and Bronsted Lowry Theories; Acid Base equilibria; Molecular dipole moments; SP3 hybridization; Conformation analysis ethane, butane and cyclohexane; Conformation of the peptide bond.
Activities: Virtual Demonstration Stereochemistry.
Unit III – Mechanisms of Substitution and Addition Reactions
SN1 and SN2 reactions on tetrahedral carbon; nucleophiles; nucleophilic addition on Acetals; Aldehyde and ketone groups; reactions of carbonyl group with amines; acid catalyzed ester hydrolysis; Saponification of an ester; Hydrolysis of amides; Ester enolates.
Activities: Demonstration of Saponification of an ester.
Unit IV – Catalysis
Chemical and biological catalysis; Catalysis and reaction energetics; Acid-Base Catalysis: Catalysis Involving Proton Donors or Acceptors; Covalent Catalysis: Catalysis Involving Covalent Bond Formation; Metal ion catalysis; Enzyme catalysis by approximation; Proximity and orientation effects in enzyme catalysis; Advantages and disadvantages of biocatalysis; Inclusion complexation.
Activities: Seminar presentation on Advantages and disadvantages of biocatalyst.
Unit V – Bioorganic Reactions
Timing of Bond formation and fission; Acyl group transfer; C-C bond formation and fission; Catalysis of proton transfer reactions; Transfer of hydride ion; Alkyl group Transfer; Terpene biosynthesis; Merrifield solid state peptide synthesis; Sanger method for peptide and DNA sequencing.
Activities: Virtual demonstration of DNA sequencing.
Course Outcomes (COs)
- CO1: Describe the core concepts of bioorganic chemistry and its application.
- CO2: Analyse and explain the bonding and stereochemistry of compounds.
- CO3: Interpret the mechanism of organic and biochemical reactions.
- CO4: Demonstrate the knowledge of biocatalyst in biochemical process.
Assessment Pattern (Quick Note)
- Weightage: Continuous Assessment 40% | End Semester Examinations 60%
- Internal methodology: Quiz (10%), Assignments (20%), Review of GATE Questions (20%), Internal Examinations (50%)
Source: Official Anna University – B.Tech. Biotechnology R-2025 Syllabus
Last Updated: September 2026
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